Stacking Peptides and SARMS
There are a few uses that Both peptides and sARMS offer.
One of the main ones is an anabolic cycle, Adding the GH releasing properties and increased IGF levels to the selective androgen receptor modulating effects of a sARM and the results can be quite suprising considering the lack of AAS and no need of a Pct following the cycle.
Firstly im going to give 2 example cycles and then explain the effects you are likely to see on cycle.
Weeks 1-8) 200mcg of semorelin 2 x ed
Weeks 1-8) 150mcg of ipamorelin first thing in the AM and at 2pm , 500mcg last thing at night.
Weeks 1-5) 25mg of Ostarine. ( you could add in s4 for the final weeks to harden up your gains and add even more fat loss at 50mg – 100mg ed.
This cycle will increase IGF levels quite dramaticaly, and offer the user improved recovery, fat loss and Muscle hypertrophy, along with deeper delta wave sleep. The addition of 500mcg of ipamorelin which is one of the most underated peptides will benefit the user with a second release of gh about 4 hours after the initial injection, if taken just before bed on an empty stomach, that should offer you a bigger pulse of gh during your Delta wave sleep.
Delta wave sleep or slow wave sleep is where a lot of our recovery and muscle growth takes place, As we know a GHRH increases this anyway, but adding the ipamorelin with its little to no influence on prolactin or cortisol will really benefit the user. You can expect to wake feeling refreshed and recovered.
What benefits will the Ostarine add?
Ostarine is a highly anabolic sARM, it offers numerous benefits not only to skeletal muscle but also by increasing igf in bones.
Androgen, one of the sex steroid hormones shows various biological activities on the corresponding various tissues. Many efforts to produce novel drug materials maintaining a desired biological activity with an adequate tissue selectivity, which is so-called selective androgen receptor modulators (SARMs) , are being performed. As one of such efforts, studies on SARMs against bone tissues which possess a significant potential to stimulate a bone formation with reducing undesirable androgenic virilizing activities are in progress all over the world. This review focuses on the research and development activities of such SARMs and discuses their usefulness for the treatment of osteoporosis.
It seems that ostarine has some of the most potent qualities in this regard of all the sARMS studied and available, my personal theory is its also the increased estrogen that seems specific to bone health is partly the reason behind Ostarines outstanding effect on bones and joints. Not only is it anabolic in muscle and allows users to see increases in muscle size and strength, it causes a decrease in fat loss, how so?
Well, it’s been shown that the higher the density of ARs, the more that lipid uptake is inhibited, It’s also been shown that androgens that bind to the AR cause an increase or upregulation of AR in adipocytes. I think the more the androgen binds to the AR, the more upregulation of AR in adipocytes occurs. This would lead to a significant reduction in subcutaneous adipose tissue, thats the fat beneath the skin.
Combining these 3 Supllements, can offer other wonderful benefits too…
Anti aging benefits of combining Peptides with sARMS
One of the benefits of a GHRH that often isnt touched on is its ability to reverse heart damage and protect the heart.
Both cardiac myocytes and cardiac stem cells (CSCs) express the receptor of growth hormone releasing hormone (GHRH), activation of which improves injury responses after myocardial infarction (MI). Here we show that a GHRH-agonist (GHRH-A; JI-38) reverses ventricular remodeling and enhances functional recovery in the setting of chronic MI. This response is mediated entirely by activation of GHRH receptor (GHRHR), as demonstrated by the use of a highly selective GHRH antagonist (MIA-602). One month after MI, animals were randomly assigned to receive: placebo, GHRH-A (JI-38), rat recombinant GH, MIA-602, or a combination of GHRH-A and MIA-602, for a 4-wk period. We assessed cardiac performance and hemodynamics by using echocardiography and micromanometry derived pressure-volume loops. Morphometric measurements were carried out to determine MI size and capillary density, and the expression of GHRHR was assessed by immunofluorescence and quantitative RT-PCR. GHRH-A markedly improved cardiac function as shown by echocardiographic and hemodynamic parameters. MI size was substantially reduced, whereas myocyte and nonmyocyte mitosis was markedly increased by GHRH-A. These effects occurred without increases in circulating levels of growth hormone and insulin-like growth factor I and were, at least partially, nullified by GHRH antagonism, confirming a receptor-mediated mechanism. GHRH-A stimulated CSCs proliferation ex vivo, in a manner offset by MIA-602. Collectively, our findings reveal the importance of the GHRH signaling pathway within the heart. Therapy with GHRH-A although initiated 1 mo after MI substantially improved cardiac performance and reduced infarct size, suggesting a regenerative process. Therefore, activation of GHRHR provides a unique therapeutic approach to reverse remodeling after MI
The hypothalamic neuropeptide growth hormone-releasing hormone (GHRH) stimulates GH synthesis and release in the pituitary. GHRH also exerts proliferative effects in extrapituitary cells, whereas GHRH antagonists have been shown to suppress cancer cell proliferation. We investigated GHRH effects on cardiac myocyte cell survival and the underlying signalling mechanisms.
METHODS AND RESULTS:
Reverse transcriptase-polymerase chain reaction analysis showed GHRH receptor (GHRH-R) mRNA in adult rat ventricular myocytes (ARVMs) and in rat heart H9c2 cells. In ARVMs, GHRH prevented cell death and caspase-3 activation induced by serum starvation and by the beta-adrenergic receptor agonist isoproterenol. The GHRH-R antagonist JV-1-36 abolished GHRH survival action under both experimental conditions. GHRH-induced cardiac cell protection required extracellular signal-regulated kinase (ERK)1/2 and phosphoinositide-3 kinase (PI3K)/Akt activation and adenylyl cyclase/cAMP/protein kinase A signalling. Isoproterenol strongly upregulated the mRNA and protein of the pro-apoptotic inducible cAMP early repressor, whereas GHRH completely blocked this effect. Similar to ARVMs, in H9c2 cardiac cells, GHRH inhibited serum starvation- and isoproterenol-induced cell death and apoptosis through the same signalling pathways. Finally, GHRH improved left ventricular recovery during reperfusion and reduced infarct size in Langendorff-perfused rat hearts, subjected to ischaemia-reperfusion (I/R) injury. These effects involved PI3K/Akt signalling and were inhibited by JV-1-36.
Our findings suggest that GHRH promotes cardiac myocyte survival through multiple signalling mechanisms and protects against I/R injury in isolated rat heart, indicating a novel cardioprotective role of this hormone.It makes a change to see a supplement that has anabolic properties, and fat loss capabilities to also have numerous health benefits, A combined therapy of GHRH and GHRP will offer neuro protection, heart protection, bone, tendon, joint and muscle strength, improved auto immune response, and increased collagen and cell turnover, yes think a bigger stronger you with better skin, and less prone to injury. Muscles get stronger quickly, and now your bones and tendons can be as strong as your muscles, aswell as improved cardio function… To much emphasis is placed on size and not enough on health, but add in Ostarine and you get both!!!
Example Anti aging cycle.
This can be run as long as you like, without fear of any health impairment.
Semorelin 100mcg morning and night.
Ipamorelin 100mcg morning and night.
And for periods of 4 weeks you can add in a sARM of your choice, over a period of time you will get bigger, healthier, stronger, and you will look better and better!
I hope you enjoy this article, but not nearly as much as you will enjoy the combination of peptides and sARMS.
Improved performance, Physique, Health, and for once its not just hype.