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AMPK and PPARδ agonists are exercise mimetics ( AICAR, GW1516 )

AMPK and PPARδ agonists are exercise mimetics SUMMARY The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore […]

Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent

Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent Abstract The purpose of this study was to examine the effect of therapeutic levels of clenbuterol, with and without exercise training, on body composition. Twenty-three unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 microg/kg body wt twice daily) plus exercise […]

Clenbuterol diminishes aerobic performance in horses

Clenbuterol diminishes aerobic performance in horses Abstract PURPOSE:  The purpose of this 8-wk study was to examine the effect of therapeutic levels of clenbuterol on aerobic performance and hemodynamics associated with exercise. METHODS:  Twenty-three unfit Standardbred mares were divided into four experimental groups, clenbuterol (2.4 microg x kg(-1) body weight twice daily) plus exercise (20 […]

Clenbuterol increases lean muscle mass but not endurance

Clenbuterol increases lean muscle mass but not endurance  Abstract Clenbuterol, a beta(2)-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in healthy subjects, and in high doses, promotes cardiac recovery. In a small, randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity […]

Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development

Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development Abstract New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in […]

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