How AOD Peptide Works: Benefits, Side Effects & Usage Guide

Young woman in a blue bra holding a weight scale while wearing oversized jeans, reflecting her weight loss journey.

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[Disclaimer: This article is for informational purposes only and does not substitute medical advice. Before starting any new peptide therapy, always consult a medical professional or fitness expert.]

Are you struggling to lose weight and improve your body shape? 

According to an analysis by a world-leading medical journal, without immediate intervention, about 260 million individuals in the USA will become obese by 2050.

Obesity further leads to several chronic health disorders, including diabetes, stroke, and liver and kidney issues. That’s why it’s essential to focus on proven and safe anti-obesity therapies.

Thankfully, shredding the excessive body fat and fighting obesity has now become easier with the AOD peptide.

This article explores what AOD peptide is, what exactly it does, how it differs from other weight loss peptides, and its dosing, cost, and side effects.

What is AOD-9604? What Does AOD-9604 Do?

The term AOD is derived from the initials of Anti-Obesity Drug or Advanced Obesity Drug. In the 1990s, scientists noticed that a particular part of human growth hormone (hGH) contains fat-burning properties. So, they isolated the AOD-9604 peptide from that area containing the most fat-dissolving potential.

As the synthetic analog of hGH, AOD-9604 mimics its weight loss properties. However, the AOD peptide does not copy the side effects associated with the use of hGH, like diabetes or glucose intolerance. That’s why a majority of obese people are now using AOD-9604 as their weight loss partner.

Note: The U.S. Food and Drug Administration recently assigned AOD-9604 the “Generally Recognized As Safe (GRAS)” status. This status reveals that any food additive is safe for its intended use according to the Federal Food, Drug, and Cosmetic Act.

Also, it’s important to know that all peptides are not equal. So, to choose the most suitable peptide for you, let’s understand the difference between different weight loss peptides.

Two clear medical vials and a syringe, ready for use.

AOD-9604 vs. Tirzepatide

Discover the distinctive features of AOD-9604 and Tirzepatide in the table below:

Aspect
AOD-9604
Tirzepatide
Category
A small fragment of human growth hormone (hGH).
Receptor agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
Action Mechanism
Imitates hGH to accelerate fat breakdown without influencing blood sugar levels.
Increases insulin secretion, reduces glucagon release, and slows emptying of the stomach to stabilize blood sugar and enhance weight loss.
Usage
Helps fat loss and reduces fat reserves (like cellulite).
Reduces appetite, aids weight loss, and mitigates type 2 diabetes.
Effect on Blood Sugar
Does not influence blood glucose levels.
Lowers blood glucose levels to stabilize glycemic levels.
Administration
Administered as daily injections, nasal sprays, or troches.
Administered as an injection once a week.

In short, AOD-9604 burns fat without influencing blood sugar levels, whereas Tirzepatide promotes weight loss by controlling hunger and managing blood sugar. However, Tirzepatide discontinuation is reported to increase weight.

AOD-9604 vs. Frag 176-191

AOD is a stable peptide since it was modified for use as an anti-obesity compound. Frag 176-191 is not modified, so it is unstable and less practical for use. 

Here’s a comparison table of AOD-9604 and Frag 176-191:

Features
AOD-9604
Frag 176-191
Composition
An hGH fragment modified for stability.
An unmodified 15-amino acid fragment of hGH.
Mechanism
Targets fat and cellulite breakdown by lipolysis without affecting blood sugar levels.
Enhances fat breakdown without influencing glucose levels.
Stability
Modified to improve metabolic processes in the long run.
Lower stability than AOD-9604; more likely to degrade early.

There’s no functional difference between AOD-9604 and Frag 176-191, except for a difference in their molecular structure. Their structures differ just because of a dissimilar amino acid. AOD has L-tyrosine in its structure, while Frag 176-191 has phenylalanine.

Row of glass medical vials with silver caps next to a syringe.

How Does AOD-9604 Work?

AOD-9604 stimulates the pituitary gland, which enhances fat metabolism in the body. To lose extra body fat, AOD performs two functions:

Enhances Lipolysis

It is a fat-burning process in which the stored fat around the abdominal section and lower back area is dissolved and used as energy. 

However, you need to complement the AOD therapy with exercise and some fasting to lose weight.

Prevents Lipogenesis

AOD peptide not only breaks down the stored fat but also prevents the formation of more fats from non-fatty food. As the AOD intake stops the calories from packing into fatty layers, you may see a prominent reduction in the mid-abdominal area.

Also, AOD peptides do not increase appetite (or cortisol levels) like the synthetic growth hormones or growth hormone-releasing peptides (like GHRP-6 and GHRP-2) do.

Did you know? Due to its fat-burning effects, AOD-9604 is recommended for hypercholesterolemia (high cholesterol in the blood) and stroke patients to reduce their cholesterol levels.

Close-up of a healthcare worker providing a subcutaneous injection.

AOD-9604 Benefits

AOD-9604 significantly burns fat and reduces weight. And this particular feature leads to some other potential benefits. 

Here’s how AOD-9604 could be beneficial for you:

Reduces Weight without Complications

The synthetic form of human growth hormone (HGH 176-191) targets fat cells. However, it also increases the level of insulin-like growth factor-1 (IGF-1) in the blood. High IGF-1 levels in the blood negatively affect the liver, heart, and joints and even cause diabetes.

AOD-9604 imitates the fat-burning properties of hGH. However, unlike growth hormones, it doesn’t interact with growth hormone receptors, so it doesn’t lead to adverse health conditions.

Therefore, AOD-9604 is preferred over synthetic hGH as it prevents:

  • Diabetes
  • Unwanted tissue enlargement
  • Other health disorders

Aids in Weight Loss by Burning Fat

Multiple animal and human studies have proved the fat-metabolizing efficacy of AOD-9604. 

According to a pre-clinical investigation, AOD-9604 treatment decreased 50% of extra body weight in rats. AOD-9604 binds to the receptors on adipose cells to enhance fat breakdown. 

After the breakdown, the fat transforms into glycerol and fatty acids. These byproducts are released into the blood to be used as energy. 

In an Australian investigation, AOD-9604 was orally administered to 300 obese individuals daily for 3 months. The AOD peptide treatment helped them lose 2.8 kgthat is three times more weight loss than people who didn’t receive the treatment. Plus, the AOD peptide improved the cholesterol profile and fixed the impaired glucose tolerance in some individuals.

Helps Bodybuilders in Muscle Retention

Anecdotal evidence indicates that AOD 9604 is a promising fat-burning peptide that may assist muscle retention and improve endurance. It is among the best peptides for athletic performance and bodybuilding, as it aids in quick muscle recovery after a workout.

Plus, it burns fat without losing lean muscle mass. AOD-9604 is often stacked with other peptides to build muscles and get a toned physique.

Note: AOD-9604 is often used during the cutting phase of bodybuilding to burn calories and aid protein synthesis to build muscles.

Bodybuilder doing cable crossover workout, emphasizing his sculpted physique and strength.

Regenerates and Repairs Damaged Tissues

A pre-clinical investigation by Korean researchers revealed that AOD-9604 stimulates cartilage regeneration and alleviates knee osteoarthritis in rabbits. The peptide also has the potential to repair tissues such as cartilage, muscles, and bones. 

In the pre-clinical study, AOD-9604 was proved to:

  • Help stem cells in the fat tissues mature into bone cells.
  • Improve cartilage health by making collagen.
  • Develop immature muscle cells into mature muscle cells.

In short, AOD-9604 may prevent bone degradation and strengthen bone density. That’s why AOD holds a prominent position among the list of peptides for arthritis.

Shows Anti-Aging Potential by Reducing Weight

AOD-9604 is mainly a fat-metabolizing peptide. However, it may show slight anti-aging potential. 

Here’s how:

  • Metabolic Effect: In obesity, excess fat layers surround the internal organs in the abdomen, which may affect metabolism and accelerate aging. AOD-9604 removes the abdominal fat and maintains optimal organ functioning.
  • Skin and Bone Health: AOD-9604 reduces cellulite in the skin and makes it firm and youthful. It also repairs cartilage and bones, which may improve mobility issues in aging populations.
  • Energy Regulation: AOD-9604 transforms fat into usable energy and improves lethargy in aging individuals.

Close-up of a person measuring their waist with a tape while wearing oversized jeans.

AOD-9604 Dosage Recommendation and Guidelines on Administration   

Here are some important guidelines regarding AOD-9604 dosage administration:

  • Acclimatize Your Body: It is better to start from a lower dose to acclimatize your body to the peptide. Later, you may increase the AOD-9604 dosage.
  • Intake Timing: Take AOD-9604 2-3 hours before breakfast, as taking this weight loss peptide on a fasting stomach accelerates the fat-burning process. You may alter this fasting duration a bit based on your tolerance level.
  • Injection Site: Keep rotating injection sites to avoid irritating the same spot.
  • Take Breaks: Some fitness experts suggest taking a break after using AOD for 20 days.
  • Take Professional Help: AOD-9604 is safe and easy to tolerate. However, in rare cases, some peptides may not suit a person and show severe reactions. In that case, it is crucial to visit any healthcare professional.

Your doctor will either change your AOD-9604 dose or change your peptide.

Close-up of a person using a nasal spray for health and wellness.

AOD-9604 Dosage Chart

You can take the AOD peptide through injections, pills, or nasal spray. The dosage of the AOD-9604 peptide will vary depending on the specific administration method and the individual’s goal.

Here’s the AOD-9604 dosage chart to get an idea about different doses based on their delivery methods:

Delivery Method Dose Notes
AOD-9604 Injections

250 – 350

 mcg daily

Take a subcutaneous (skin) injection in the abdominal area on an empty stomach before breakfast.
AOD-9604 Pills

500 – 1000

mcg daily

Take one (dissolvable) pill in the mouth 45 minutes before mealtime. The pill will slowly get absorbed in the mouth.
AOD-9604 Nasal Spray 1000 mcg/mL
(1-2 sprays) daily
Take 1-2 spray puffs in a single nostril half an hour before breakfast. If prescribed, take a second dose before dinner.

A daily dosage of 300 mcg through subcutaneous injections has been proven to be most effective for the majority (as per anecdotal evidence).

Note: Use an AOD-9604 dosage calculator to determine how much reconstituted AOD peptide (dissolved in bacteriostatic water) to draw in the syringe.

AOD-9604 Side Effects

AOD-9604 is well-tolerated and labeled as safe by the U.S. FDA. Being a safe alternative to synthetic hGH, AOD peptide does not cause diabetes or unwanted growth effects.

However, it may show a few temporary and mild side effects, including:

  • Flushing
  • Chest tightness
  • Slight fever
  • Diarrhea
  • Headaches
  • Indigestion
  • Palpitations
  • Euphoric feelings
  • Cough
  • Fatigue

Note: Seek immediate medical help if the symptoms worsen or don’t resolve in 1-2 days.

A person lying on a bed with their legs raised and hands on a pillow, in a sunlit room.

AOD-9604 Cost

‍The cost spectrum of AOD 9604 depends on multiple factors, including quality, form (injections, tablets, or nasal spray), treatment duration, and AOD-9604 peptide dosage. 

For reference, one month of oral 500 mcg AOD-9604 dosage (30 dissolvable pills) costs approximately $300. A 5 mg vial of AOD-9604 costs around $52.

Also, note that insurance companies do not cover the cost of AOD-9604 peptide therapy as this peptide treatment is considered cosmetic or elective.

So, you need to manage finances out of your pocket and consider them a long-term health investment.

Where to Buy AOD-9604

One of the most trustworthy peptide suppliers in the United States is Biolongevity Labs. We ensure that we provide pure, concentrated peptides devoid of fillers like sucrose or mannitol.

Here’s why you should opt for Biolongevity Labs:

  • Unmatched purity
  • Independent third-party testing in U.S. labs
  • Amazing customer support

Remember that going for the lowest range will cost your health and money. So, always invest in products that offer value for your money.

Sterile syringe with a visible droplet, ready for medical or cosmetic use.

Tips for Maximizing Efficacy of AOD-9604 Peptide

To maximize the efficacy of the AOD-9604 peptide, follow the tips below:

  • Administration Route: While AOD-9604 is available as a nasal spray or troche, it is best to take it via subcutaneous injections. Subcutaneous injections (that too on an empty stomach) ensure the highest absorption rate.
  • Drug Interactions: AOD-9604 tends to interact with other drugs, supplements, or peptides. So, if you are simultaneously using multiple formulations, it is best to consult with a doctor for a tailored peptide treatment plan.
  • Peptide Storage: Store the AOD-9604 peptide in the refrigerator at 2 to 8°C (35.6 to 46.4°F) to keep it usable for four weeks. Remember that even if you keep it in the refrigerator, the reconstituted AOD-9604 will expire after four weeks.

Sterile medical vial containing clear liquid, held by a hand in blue gloves.

Frequently Asked Questions (FAQs)

Here are answers to the common questions you might have regarding AOD-9604 peptide therapy:

What’s the Difference: AOD-9604 vs. Semaglutide?

Read the table below to discover the distinct features of weight loss drugs AOD-9604 and Semaglutide:

Features AOD-9604 Semaglutide
Action Mechanism Imitates human growth hormone (hGH) to improve metabolic health and reduce stubborn fat reserves. This GLP-1 receptor agonist reduces hunger, keeps you full, and maintains blood sugar levels.
Primary Use Suggested for people with extra body fat and metabolic issues. Mostly for people with increased weight and type 2 diabetes.

Semaglutide has undergone more successful clinical trials. It is one of the best weight loss drugs, especially for type-2 diabetes patients, as it reduces hunger and regulates blood sugar levels. 

On the other hand, AOD-9604 reduces weight by targeting fat reserves.

Can AOD Peptide Be Combined with Other Peptides?

Yes, AOD-9604 can be combined with the other peptides. For example, AOD-9604 is often combined with the BPC-157 peptide for synergistic effects on metabolic health. AOD increases the burning process, while BPC-157 improves gut health and overall physical healing, including cartilage repair and regeneration.

Additionally, some fitness enthusiasts pair AOD-9604 with Tirzepatide or Semaglutide for major weight loss outcomes.

How Quickly Can I See Results with AOD Peptide?

Most people take AOD for 12 weeks before they notice any weight changes. However, the question of how much weight and how quickly is subjective. Multiple factors, like genetics, metabolic rate, health status, and age, influence weight loss outcomes.

Those with a family history of obesity may not get as quick and better AOD-9604 results as others. Having said that, following the right AOD-9604 dosage regimen, along with regular exercise and a balanced diet, is crucial to getting significant results.

Is AOD Peptide Suitable for Women?

Multiple clinical and pre-clinical studies conducted on male and female animals revealed that AOD-9604 is safe for both genders. To date, no side effects have been reported on the gynecological or reproductive health of women.

That’s why AOD-9604 is one of the best peptides for female fat loss. However, we highly recommend that pregnant or breastfeeding females consult their gynecologist before taking any supplement or peptide.

Conclusion – AOD Peptide

AOD-9604 is a popular anti-obesity peptide. While individual results may vary, numerous before-and-after success stories reveal dramatic reductions in stubborn body fat and noteworthy improvements in body composition.

To maximize the weight loss benefits of AOD-9604, it’s crucial to pair the peptide therapy with a low-calorie diet and regular exercise. This fat-burning partner works steadily to burn stubborn fat layers and help you get your dream physique.

Ready to take the first step? Your weight loss journey starts today!

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