[Disclaimer: This article is not a substitute for medical advice. It is for informational purposes only. While early findings of SLU-PP-332 seem promising, its long-term safety has not been established yet. Consult a medical professional before you start using it.]
Do you want to lose weight without working out much? Or do you find it hard to exercise due to physical constraints?
Well, researchers have formulated a molecule called SLU-PP-332 that shows exercise-mimicking effects. Although extensive human trials are needed before using it as an exercise-mimicking drug, it has tremendous potential to complement weight loss therapies in humans.
In this article, we will explain what SLU-PP-332 is, how it works, its benefits, dosing, and SLU-PP-332 side effects. Also, you will find out whether this ERR agonist affects hormones.
What is SLU-PP-332?
SLU-PP-332 is a synthetic pan-agonist for estrogen-related receptors (ERR), including ERRα, ERRß, and ERRγ. That means it activates multiple receptors of the same (ERR) family, with a slightly higher inclination towards ERRα, making it a therapeutic compound in metabolic diseases.
Estrogen-related receptors (ERRs) are like mini switches that control multiple metabolic and energy-regulating processes in the tissues and organs with high energy demand, including the heart, muscles, brain, liver, and fat tissues.
How SLU-PP-332 Works?
SLU-PP-332 is rightly named “exercise in a pill”. As an exercise mimetic, it tricks the body into feeling that it is exercising even during rest.
“[SLU-PP-332] directs skeletal muscles to make the same physiological changes as endurance training,” said Thomas Burris, a professor at the University of Florida.
SLU-PP-332 activates genes that could otherwise be activated only by aerobic exercise. Additionally, by working as an ERR agonist, SLU-PP-332 fuels the tissues by enhancing metabolism and rate of fat breakdown without increasing appetite.
Also, it enhances the ability of muscles to use oxygen and improves cardiovascular function. The dual activity of fat reduction and muscle preservation also holds an anti-aging value as it may reduce age-related muscle decline.
According to an ACS news release, the exercise-mimicking pill may mitigate muscle atrophy and enhance the physical fitness of individuals with heart failure, cancer, or neurodegenerative disorders, such as dementia.
Note: SLU-PP-332 holds potential for aging individuals due to its muscle-preserving tendency. However, it is not officially recognized among the list of anti-aging peptides.
SLU-PP-332 Benefits
Clinical trials related to SLU-PP-332 are still underway. Therefore, any known SLU-PP-332 benefits are derived from pre-clinical research and anecdotal evidence, as shown below:
Burns Fats and Alleviates Obesity
During diet or exercise, skeletal muscles use glucose as the main energy source. However, during higher or prolonged energy demand in high-load resistance or aerobic exercise, skeletal muscles start using fatty acids to get energy.
SLU-PP-332 exerts a similar effect.
A pre-clinical study published in the Journal of Pharmacology and Experimental Therapeutics by the Washington School of Medicine indicated the mitigative role of ERRα-targeting compound (aka SLU-PP-332) in metabolic syndrome, including obesity and type-2 diabetes.
The mice treated with SLU-PP-332 had 12% less weight and gained ten times less fat than untreated mice despite eating the same high-fat diet in a similar quantity.
SLU-PP-332 treatment in mice showed that the compound:
- Depletes fat reserves
- Enhances metabolic function
- Preserves lean muscle mass
- Alleviates obesity
It was concluded that SLU-PP-332-treated mice used their fat reserves.
An SLU-PP-332 user shared their experience:
I take 100mcg of SLU-PP-332 before my workouts. It’s an exercise mimetic. I’m not going to explain that. You can look it up. It keeps my weight stable, makes me sweat a ton, and gets my heart rate going like a typical pre-workout.
Enhances Insulin Sensitivity and Mitigates Type 2 Diabetes
The above research and anecdotal evidence revealed that SLU-PP-332 improves insulin sensitivity and aids in glucose uptake by skeletal muscles during exercise. So, if you are diabetic, you might need less insulin than usual before and after meals.
Also, the pre-clinical study mentioned above showed that it helps maintain blood sugar levels, even without physical exhaustion or dietary alterations.
That’s why SLU-PP-332 is truly an exercise mimetic that may improve metabolic health if used in optimum quantity.
Improves Heart Function and Prevents Heart Failure
Exercise-mimicking potential of SLU-PP-332 improves cardiac and blood vessel function. It enhances circulation and helps the heart cells handle stress efficiently, similar to the cardiac benefits of exercise.
In pre-clinical research, SLU-PP-332 improved the heart function of mice with cardiac failure. It:
- Improved the blood-pumping capacity of the heart (called ejection fraction)
- Boosted the function of mitochondria (the mini powerhouse of cells)
- Prevented heart stiffening and reduced cardiac fibrosis
It was concluded that SLU-PP-332 could be used as a therapeutic compound against heart failure due to its potential to metabolize fatty acids and improve mitochondrial function.
Enhances Endurance and Stamina
During aerobic exercise, mitochondria (the energy factory of cells) work efficiently, and muscles use oxygen to produce energy.
According to pre-clinical research, mice were made to exercise until exhaustion on a rodent treadmill. Mice treated with SLU-PP-332 could run 45% further and 70% longer than untreated mice.
The results showed:
- Muscle Fibers Increase: SLU-PP-332 reportedly increased skeletal muscle fibers (type IIA) in mice. Type II muscle fibers (called fast-twitch muscle fibers) are present in the chest, triceps, biceps, biceps, and quadriceps in humans. These muscle fibers generate energy bursts in the upper body during resistance training.
- Development of Fatigue-Resistant Muscles: According to research, SLU-PP-332 boosts cellular respiration and mitochondrial function to provide sustained energy for a workout without physical exhaustion. Also, SLU-PP-322-treated mice developed fatigue-resistant muscles that were better suited for sustained workouts.
In short, SLU-PP-332 may improve muscle performance and enhance endurance, which could be helpful for fitness enthusiasts during tough and prolonged workouts.
A user shared his experience with SLU-PP-332, saying:
Going pretty good. Do not take this in evening you will not be able to sleep. Your heart rate will be higher than normal through the day I can feel the burst of energy and I can definitely tell that it adds stamina and endurance.
Provides Muscle Recovery
SLU-PP-332 reportedly enhances muscle recovery, particularly after physical exertion. Here’s how:
- Energy Metabolism: It preserves lean muscles by improving the usage, storage, and transformation of nutrients into energy fuel.
- Mitigates Liver and Kidney Problems: A pre-clinical study published in The American Journal of Pathology indicated the protective role of SLU-PP-332 for aging kidneys. SLU-PP-332 treatment for two months improved kidney health in mice by:
- Reducing protein leakage into the urine (called albuminuria)
- Improving the kidney cells’ (aka podocytes) function to prevent protein leakage
- Reducing scarring or fibrosis in tissues
- Reducing kidney stress
In short, SLU-PP-332 reduced kidney damage caused by aging. The study raised hopes that it may act as a therapeutic agent for kidney issues in older individuals.
The pre-clinical research by the Washington School of Medicine also reported that SLU-PP-332 decreases triglycerides in the liver. Triglyceride buildup in the liver could lead to liver failure, insulin resistance, and inflammation. However, it may alleviate fatty liver disease and metabolic disorders by reducing triglycerides.
Boosts Mental Health
It is well-understood that exercise boosts mood and mental function. In earlier studies, exercise-mimicking compounds have enhanced cognitive health. Being an exercise mimetic, SLU-PP-332 treatment may also improve mental state, enhance mood, and reduce stress.
It may reduce stress and increase mental capacity for those performing stressful or mentally demanding activities. Previous research has shown the tendency of ERRα as a therapeutic compound for Alzheimer’s disorder.
However, this area still needs to be investigated in animals before its testing starts in human subjects.
SLU-PP-332 Dosage
There’s no approved SLU-PP-332 dosing regimen. However, anecdotal evidence suggests a few dosage protocols. You may choose what works best for you.
Start Small: Take 100 micrograms (mcg) twice a day at the start. Most individuals notice its effects within 10 days.
Take a Break: After SLU-PP-332 dosage intake for 6 weeks, take a minimum of 2 weeks before resuming another cycle to prevent receptor desensitization.
Optimum Dosage: Then divide 400 or 500 mcg of daily SLU-PP-332 dosage into two chunks. Here’s how you can manage the SLU-PP-332 dosage regimen:
- The first-morning dose could be 200 mcg or 250 mcg in fasted condition 30 minutes before cardio.
- The second dose is 200 or 250 mcg, about one and a half hours after lunch.
Remember, moderation is the key.
Exercise-mimicking pills (like exercise) have catabolic (breakdown) effects. That means protein synthesis is suppressed, autophagy (cell recycling) is enhanced, and mTOR (growth-encouraging protein) is deactivated.
Meanwhile, recovery, rest, and protein intake after exercise will make you bigger and stronger. So, if you take a high dose of SLU-PP-332, the catabolic switch will remain turned on. And that would not be good for your health in the long run.
We suggest you start with a low dose (100 mcg twice daily). Otherwise, take only a single 250 mcg dose daily to check your tolerability. Starting small gives your body a chance to adapt to this exercise-mimicking molecule.
After that, you may gradually move to the optimum dosage (400-500 mcg daily).
Note: Consult your healthcare provider before choosing a dose or starting SLU-PP-332 therapy. If you have underlying health conditions, regularly monitor metabolic and cardiovascular markers.
Best Practices for SLU-PP-332 Administration
Here’s how you can administer the SLU-PP-332 dose for better results:
SLU-PP-332 Administration in Animal Models:
For SLU-PP-332 administration in animal models, it is dissolved in the solvent (ethanol or DMSO) and then administered through intraperitoneal injections (in the abdomen).
SLU-PP-332 Administration in Humans:
Since the human trials are underway, we can only rely on anecdotal evidence for administering SLU-PP-332 in humans.
SLU-PP-332 Pills
SLU-PP-332 is mostly available in the form of pills or capsules. They can be orally administered with water (mostly) on an empty stomach before exercise.
SLU-PP-332 Injections
SLU-PP-332 is subcutaneously injected (through the skin) for optimal bioavailability as follows:
- For injections, the formulation is available in powdered form, which is reconstituted in bacteriostatic water before injecting the dose.
- Subcutaneous injections are mostly injected in the abdomen. However, you can also inject in the thigh, upper-outer part of buttocks, or back of arms.
- Before injection, clean the injection area with an alcohol swab.
- After injection, gently massage the area to help absorption.
Note: Rotate the injection site frequently to prevent repeatedly irritating the same area.
Potential Side Effects of SLU-PP-332
Although pre-research has proved its exercise-mimetic benefits, SLU-PP-332 treatment is not yet approved for regular human use. However, several fitness enthusiasts are using it to reap its benefits.
According to pre-clinical research, it is safe to use, and there are hardly any SLU-PP-332 side effects. No toxicity is reported in mice after treating rats with 50 mg/kg of SLU-PP-332 twice daily for 10 days.
Also, anecdotal evidence has shown the positive SLU-PP-332 results. However, some individuals may experience hot flashes due to using higher doses.
Overall, SLU-PP-332 is well-tolerated. It does not seem to:
- Increase blood glucose
- Increase appetite
- Affect pancreas function
- Increase liver enzymes
- Decrease insulin levels
Having said that, although SLU-PP-332 reduces the levels of triglycerides and total cholesterol, the studies mentioned above show that it may not reduce bad cholesterol (LDL). Also, it could decrease the good cholesterol (called HDL). That’s why it may not be the best for those with a bad lipid profile.
Where to Buy SLU-PP-332?
Since SLU-PP-332 is in the research phase, it is not commercially available. The compound is currently available only as a research-grade supplement.
However, SLU-PP-332 has started getting attention from athletes and researchers. Once it becomes available, it is important to find trustworthy sellers that prioritize the purity of its products.
Since it has not yet been approved, it is unavailable on Amazon. However, you can buy SLU-PP-332 online from any reputable source that sells it as a research compound.
Frequently Asked Questions (FAQs)
Read the answers to your frequently asked questions below:
Can SLU-PP-332 Affect Fertility?
Research on SLU-PP-332 is still underway. No study is yet available on its role in fertility, but anecdotal evidence has shown its positive role in multiple organ systems.
However, we suggest avoiding SLU-PP-332 if you are a pregnant or lactating woman since the need for prevention and precautions increases manyfold during these early phases of motherhood.
Is SLU-PP-332 Safe for Long-Term Use?
According to preclinical research published in bioRxiv, long-term SLU-PP-332 treatment in mice (for 15 days) positively affected the physiology of their muscles. Their muscles also showed more succinate dehydrogenase (SDH) enzymes and improved oxidative activity.
Higher SDH levels and better oxidative activity indicate that their muscle cells produced more energy using oxygen. Plus, the body had fatigue-resistant muscles, high endurance, and an efficient metabolism, which allowed muscles to work more efficiently.
However, this pre-clinical research was insufficient to establish its safety profile. Additionally, SLU-PP-332 human clinical trials are needed to truly validate its safety in humans.
Are there any Gender-Specific Side Effects of SLU-PP-332?
No gender-specific side effects have been reported so far. Men, especially bodybuilders, might think that SLU-PP-332 (being an ERR agonist) may increase female hormones, including estrogen.
However, researchers revealed that SLU-PP-332 cannot increase estrogen levels since it does not interact with estrogen receptors responsible for hormone binding. Therefore, it does not show any feminizing effect in males or hormonal fluctuations in females.
Conclusion – SLU-PP-332 Side Effects
SLU-PP-332 imitates the effects of exercise on the body, even if you are not involved in physical exertion. But that does not mean it should replace exercise. It should rather be used to enhance your training outcomes.
Also, the exercise-mimicking effect could be valuable when working with physically restricted research subjects in experimental conditions.
It could be a perfect match for those unable to perform physical activities due to health constraints. However, it is recommended that people be cautious and wait until the clinical trials establish their dosing, side effects, and safety for humans.
