[Disclaimer: This article is for educational purposes only and is not a substitute for medical advice. Always consult a medical professional before starting any hormonal therapy, including pregnenolone.]
Pregnenolone is a neurosteroid hormone that regulates memory and cognitive health. It also plays a key role in synthesizing other hormones, including testosterone.
That’s why supplementation is becoming a popular option for people, especially males, experiencing cognitive decline, including memory issues or brain fog.
However, pregnenolone supplementation holds a few risks. This article sheds light on pregnenolone side effects in males, how much pregnenolone a man should take, and who is not eligible for pregnenolone supplementation.
The article also explores the role of pregnenolone in mood disorders, fatigue, mental health, and sexual health, especially in middle-aged and older individuals.
Let’s dive in.
What is the Pregnenolone Hormone?
Pregnenolone is a natural steroid hormone synthesized mainly in the brain, gonads, and adrenal glands. It is a precursor to other hormones, including testosterone, progesterone, estradiol, estrogen, and cortisol.
In the body, cholesterol is converted into pregnenolone, which acts as the building block for other hormones. That’s why this hormone is also called the Mother Hormone. This implies that optimum pregnenolone levels are necessary to maintain hormonal balance.
Pregnenolone levels are highest in adult males. However, this hormone drops with age. Research shows that approximately 40 % of individuals over 65 years of age face poor memory due to aging.
Due to low pregnenolone levels, the body cannot synthesize other hormones, which disrupts the entire hormonal balance of the body. Additionally, low pregnenolone levels may lead to reduced attention span, joint and muscle pain, dry skin, fatigue, and low sex drive.
Who Can Use Pregnenolone?
Being an anti-anxiolytic and anti-depressing steroid, pregnenolone is mainly recommended for those with psychiatric conditions like bipolar disorder, schizophrenia, autism, anxiety, brain fog, depression, and drug addiction.
Research indicates that the hormone can improve memory, concentration, and mental clarity.
Benefits of Pregnenolone for Men
Pregnenolone facilitates multiple physical and mental processes in men. It is reported to alleviate mood disorders, chronic pain, multiple sclerosis, high cholesterol, hypothyroidism, and rheumatoid arthritis.
Let’s explore the additional benefits of pregnenolone for men below:
Mitigates Anxiety and Depression
Pregnenolone is the precursor of allopregnanolone, which controls mood and emotional state through the central nervous system. High allopregnanolone levels are an aid in reducing anxiety.
Additionally, pregnenolone regulates stress hormone (cortisol) levels to control negative emotions and enhance mood. Therefore, it is important to have optimum pregnenolone levels for good mental health.
Reduces Schizophrenia Symptoms
In a review published in the Australian and New Zealand Journal of Psychiatry, pregnenolone therapy improved cognitive health and enhanced gene functioning of schizophrenic individuals. In an investigation, one month of pregnenolone treatment mitigated the condition at the start in individuals who had not yet started antipsychotic medication.
In another study published in the Journal of Clinical Psychiatry, 30 mg of pregnenolone was daily given to chronic schizophrenia patients for 2 months.
This treatment:
- Improved their ability to focus
- Enhanced their ability to remember information temporarily (called working memory performance)
In another clinical study published in Neuropsychopharmacology journal, researchers provided 500 mg of pregnenolone to schizophrenia patients daily for 2 months. The results showed:
- Improvement in the inability to feel pleasure (called anhedonia)
- Reduced speech difficulty (aka alogia) to talk like normal people
- Improved ability to express emotions (called affective flattening)
Therefore, it was revealed that pregnenolone could act as a therapeutic compound for those struggling with schizophrenia.
Alleviates Autistic and Bipolar Symptoms
Research says that pregnenolone regulates bodily substances, like MAPs (microtubule-associated proteins), for normal brain functioning. However, an imbalance in MAP levels leads to major depressive disorder.
In a small-scale investigation published in the Journal of Affective Disorders, the role of pregnenolone was evaluated in bipolar depression patients. Six weeks of pregnenolone supplementation stabilized their MAP levels and alleviated the depressive symptoms.
Another study published in the Journal of Autism and Developmental Disorders reported that pregnenolone supplementation alleviated autism spectrum disorder by:
- Improving social withdrawal and irritability
- Enhancing sensory processing
Research published in Psychiatry Research assessed the effect of pregnenolone on participants with manic depression (aka bipolar disorder). Results showed that pregnenolone hormone treatment decreased their depression and reduced their mood swings.
These studies indicate the role of pregnenolone in the alleviation of mood disorders, including autism and bipolar disease.
Reduces Drug and Alcohol Cravings
A study published in Psychopharmacology indicated that pregnenolone supplementation may assist people with alcohol use disorder in reducing their drinking addiction.
Researchers gave the participants 300 mg of pregnenolone daily. These people had fewer alcohol cravings even after getting drinking cues or stress.
In another investigation published in Biomolecules journal, pregnenolone supplementation:
- Decreased stress and cue-induced cravings for cocaine
- Reduced stress and anxiety levels (some people prefer the BPC-157 peptide to mitigate stress)
In short, pregnenolone regulates brain activities and behavior. By modulating the nervous system, this neurosteroid may help people with drug dependence, including alcohol, cocaine, and cannabis.
Boosts Immunity
High stress increases cortisol (stress hormone) release.
High cortisol levels negatively affect immune function. According to a study published in the Journal of Pharmaceutical Research International, pregnenolone improves immune response and enhances the body’s capacity to reduce the risk of diseases and infections.
Reduces Chronic Back Pain
In a study published in JAMA Network Open, pregnenolone therapy was given to 94 US military veterans with chronic low back pain. One month of neurosteroid treatment reduced their back pain intensity.
Therefore, you may take pregnenolone treatment in combination with other therapies, but after doctor’s advice.
Potential Side Effects of Pregnenolone
Pregnenolone is well-tolerated. However, it may cause minimal side effects to very few individuals, especially with prolonged use or high dosages.
However, we have mentioned all the possible side effects of pregnenolone that some people may experience.
General Side Effects of Pregnenolone
The pregnenolone side effects depend on the individual’s health, hormonal balance, and hormone dosage.
Here are some general side effects of pregnenolone:
- Acne
- Headache
- Nausea
- Hair loss
- Sweating
- Insomnia and weird dreams
- Increased appetite
- Difficulty breathing
- Skin rashes and itching
- Facial hair growth
- Drowsiness or tiredness
- Libido changes
- Upset stomach and diarrhea
- Excitement or overstimulation
- Muscle stiffness or pain
- Dizziness or tiredness
- Heart palpitations or heartburn
- Cold sensation in fingers, hands, toes, or feet
- Mood swings (like anxiety, agitation, or anger)
In females, pregnenolone supplementation may cause menstrual irregularities.
Pregnenolone Side Effects in Men
As far as pregnenolone side effects in men are concerned, high pregnenolone dosage disrupts the hormonal balance, reducing testosterone synthesis over time.
Additionally, being a precursor to several hormones, pregnenolone may increase estrogen levels, leading to gynecomastia (breast tissue enlargement) and mood swings.
Side effects take some time to subside. To mitigate the adverse effects, you may reduce the dosage to half. However, if side effects are severe, discontinue the pregnenolone intake and consult your medical practitioner.
Pregnenolone Effects on Testosterone Levels
Pregnenolone is a precursor to testosterone and other hormones. However, it does not directly escalate testosterone levels. Pregnenolone works to produce multiple hormones in the body, including testosterone.
Changes in pregnenolone levels could affect testosterone production, especially in aging men. To restore levels, add HCG (human chorionic gonadotropin) to your treatment regimen. It will use cholesterol to make pregnenolone and stabilize the hormonal levels in the body.
Here’s what progesterone does to improve the reproductive issues of males and females:
- Improves Sexual Health: High pregnenolone levels increase testosterone, which may affect sexual health. Low pregnenolone levels may show changes in libido and cause sexual problems in men, including erectile dysfunction.
Besides pregnenolone, people also use some peptides for libido to increase their sexual desire.
- Alleviates Menopause and Andropause: By increasing the synthesis of sex hormones, including testosterone, progesterone, and estrogen, pregnenolone may decrease symptoms of menopause and andropause.
You may explore the peptides for menopause to deal with the declining reproductive hormones (estrogen, progesterone, and testosterone).
Pregnenolone Effects on Cognitive Function
Pregnenolone concentration is highest in the brain. The steroid hormone protects the nervous system from high cortisol levels, preventing neural damage. Pregnenolone improves the connection between the brain and body to improve focus, cognitive health, and mental functions related to memory and learning.
However, pregnenolone decrease (especially while aging) adversely affects the capacity to focus and remember things.
Here’s how pregnenolone treatment enhances cognitive function:
- Improves Memory and Focus: Pregnenolone shows neuroprotective effects by repairing the nerve covering (called the myelin sheath). Also, the hormone strengthens the aging-induced decline in the neurotransmitter system (the body’s messaging network).
In a preclinical study published in the European Journal of Pharmacology, intranasal administration of pregnenolone improved memory and reduced anxiety in mice.
Besides, this neurosteroid stimulates acetylcholine release to aid mental processes related to memory.
- Alleviates Alzheimer’s Disorder: Inflammation leads to several inflammatory disorders like Alzheimer’s disease. Research revealed that Alzheimer’s patients have low pregnenolone levels. By fighting inflammation, pregnenolone may alleviate inflammatory conditions like Alzheimer’s disorder and arthritis.
Based on the research and strong anecdotal evidence, pregnenolone supplementation seems to be a game-changer in enhancing memory and cognitive healing, particularly in elderly people.
Who Should Not Take Pregnenolone?
Avoid pregnenolone supplementation if you have the following conditions:
- Hormone-Sensitive Conditions: Pregnenolone is a building block for other hormones, so those with hormone-sensitive conditions (like breast cancer, ovarian cancer, prostate cancer, uterine cancer, uterine fibroids, or endometriosis) should avoid pregnenolone supplements.
Also, the neurosteroid can disturb the endocrine system and, ultimately, the menstrual cycle in women.
- Seizures: GABA receptors aid in calming down the overactive nerve signals. However, pregnenolone has an antagonistic role on GABA receptors. By disrupting the calming effect, pregnenolone may cause issues for individuals with a seizure history.
Additionally:
- Avoid Intake with Other Hormones: Pregnenolone makes other hormones in the body. So, using it with other hormones like birth control pills, testosterone pills, or estrogen could increase these hormonal levels in the body. Therefore, avoid taking pregnenolone with other hormones, especially without a doctor’s advice.
- Avoid Intake with Sedative Drugs: Pregnenolone could reduce the sleep-inducing effect of sedative medicines, such as benzodiazepines or diazepam. So, be cautious with pregnenolone intake if you are already taking sedative medications.
Note: Using pregnenolone with other medications (like blood thinners, birth control pills, drugs for thyroids, or hormone replacement therapy) can affect their effectiveness or increase side effects. Consult with a medical professional before pregnenolone supplementation, especially if you are taking other medications/supplements or have health conditions.
Pregnenolone Dosage Guidelines
Pregnenolone is used for numerous health disorders, including hormonal imbalances and mental conditions. It does not have a single specified dosage for all.
Its dosage depends on the individual’s age, health conditions, and specific goals.
Still, let’s look at a few guidelines for pregnenolone dosage:
General Recommendations for Pregnenolone Dosage
A few experts suggest pairing pregnenolone with DHEA for cognitive decline and hormonal imbalance, especially in aging individuals.
Follow the following recommendations regarding pregnenolone dosage:
- Average Pregnenolone Dosage: According to anecdotal evidence, the average pregnenolone dose ranges between 50–200 mg daily. Take the hormone on an empty stomach in the morning to align with the body’s natural hormone peaks.
- Dosage for Sensitive Individuals: Anecdotal evidence suggests that individuals with higher sensitivity should take lower dosages, i.e., 25–50 mg daily. This dosage can also be split into morning and evening doses.
- Clinical Dosage for Mental Conditions: According to the clinical study published in the Neuropsychopharmacology journal (linked above), a daily dose of 500 mg of pregnenolone proved to be well-tolerated for mental conditions like fatigue and mood disorders.
For a more relaxing effect, a higher ratio of Pregnenolone: DHEA is suggested. On the other hand, a higher ratio of DHEA: Pregnenolone is more energizing and stimulating.
Pregnenolone Dosage Based on Specific Conditions
Pregnenolone is mostly used with other hormones the patient requires based on their laboratory reports and symptoms.
Anecdotal evidence suggests the following doses for different conditions:
- Age-Related Hormone Imbalance: 50–100 mg pregnenolone
- Brain Damage/Post-Traumatic Stress Disorder (PTSD): 100–150 mg pregnenolone + 25–50 mg DHEA
- Chronic Pain: 200–500 mg pregnenolone + 100–200 mg DHEA
A pregnenolone dosage of more than you need could affect your hormonal and mental health. So be cautious while starting pregnenolone therapy.
Note: Start with a low dosage (like 10–25 mg daily) and gradually increase to prevent pregnenolone risks.
Pregnenolone Administration Route
The following are the common routes for pregnenolone administration:
- Oral Capsule/Tablet: Metabolism of pregnenolone in the liver could decrease its bioavailability. Therefore, sustained-release tablets are the preferred form of pregnenolone supplementation.
- Transdermal or Sublingual: After tablets, transdermal or sublingual methods are opted for as they bypass liver metabolism. Also, these methods ensure good brain accessibility and hormonal balance.
Other administration routes (like subcutaneous, intravenous, intranasal, or topical) are also used, depending on the need.
Note: Blood tests are important to keep hormonal levels in check and adjust pregnenolone dosage accordingly. Consult an endocrinologist or physician for personalized advice and a tailored dosage regimen.
Frequently Asked Questions (FAQs)
Get answers to the common questions regarding pregnenolone therapy below:
What Are the Long-Term Effects of Pregnenolone?
According to a study published in the Journal of Autism and Developmental Disorders (linked above), pregnenolone supplementation is well-tolerated for up to 12 weeks. However, a few users reported side effects like digestive issues, muscle pain, insomnia, and anxiety. The fact is no study has addressed the long-term effect of pregnenolone yet.
However, being a precursor to other hormones, pregnenolone influences hormonal balance. Therefore, its long-term use could cause hormonal changes and side effects (like mood swings, libido changes, or other symptoms linked with hormonal imbalance), especially in people with high health sensitivity.
Can Pregnenolone Cause Sleep Disturbances in Males?
Well, it depends on the dosage, supplementation timing, and the individual’s sensitivity to hormonal changes. While pregnenolone is known to improve sleep, this stimulating hormone can also cause insomnia or weird dreams in some people, especially if administered at inappropriate times during the day (anecdotal evidence).
If you face sleep disturbances due to pregnenolone, consult your doctor to discuss your need for changes in dosage or administration timing.
Is Weight Gain a Possible Side Effect of Pregnenolone for Men?
Pregnenolone has the tendency to increase estrogen levels. Therefore, a few users may experience water retention and bloating rather than weight gain.
Remember, individuals respond differently to the pregnenolone supplementation. So, in rare cases, a few men may face slight swelling or puffiness due to hormonal fluctuations.
Conclusion
Pregnenolone neurosteroid is therapeutic to the nervous system, improving mood disorders and cognitive function. Being a mother hormone, pregnenolone levels affect the hormonal equilibrium in the body.
Optimum pregnenolone levels are crucial for the production of other hormones (including testosterone) and overall hormonal health, especially if you are having TRT or HRT (hormone replacement therapy).
Additionally, pregnenolone aids testosterone production and improves sexual health in men. However, it can cause side effects in a few individuals, including digestive discomfort, muscle pain, insomnia, or mood swings.
For those considering starting pregnenolone treatment, it is crucial to start with a lower dosage and slowly increase the dose to the optimum level to keep adverse effects in check.
