Selank Peptide Dosage Chart and Calculator

Selank is a synthetic peptide developed in Russia with anxiolytic and nootropic properties that may help reduce anxiety, boost brain function, and manage stress. This Selank dosage guide offers detailed dosing info based on current research and real-world use to help qualified professionals create proper peptide treatment plans.

Individuals should always use Selank under medical supervision of a healthcare professional, as responses vary from person to person.

Introduction to Selank

Selank is a synthetic peptide made from tuftsin, a natural substance that helps with immune function. Research shows it affects neurotransmitters like serotonin, which may help with calm, focus and mental clarity.¹

Scientists at Russia’s Institute of Molecular Genetics created Selank by taking the tuftsin sequence (Thr-Lys-Pro-Arg) and adding Pro-Gly-Pro at the C-terminus, giving it a molecular weight of 751.86 g/mol. Russia has approved Selank for treating anxiety disorders, but most other countries still consider it a research chemical.

Selank is valued for its potential to reduce anxiety without the sedative effects or addiction risk associated with traditional anxiolytics.

Selank Peptide Calculator

Selank’s Mechanism of Action

Selank works through several pathways in the brain. It interacts with GABA receptors and affects serotonin, dopamine, and norepinephrine levels. It also increases brain-derived neurotrophic factor (BDNF), which may explain how it enhances thinking and memory.

Research shows Selank can change the production of interleukin-6 (IL-6) and other cytokines, suggesting it may help regulate the immune system. These different mechanisms help explain why Selank might be useful for treating more than just anxiety.

Administration Methods

Intranasal (Nasal Spray)

Intranasal delivery (through the nose) is the best way to take Selank. This method works well because it prevents digestive enzymes from breaking down the peptide, which would happen if taken by mouth.

It also efficiently delivers the substance to the bloodstream and brain. Research shows this nasal route works optimally for getting peptide molecules to the central nervous system. Selank nasal sprays typically come in concentrations from 0.15% to 1.25mg/mL.

Subcutaneous Injection

Subcutaneous injection is another effective method to take Selank, giving you exact doses. For this method, Selank is injected into the stomach’s fat layer, about 2 inches from the belly button.

This approach allows Selank to enter the bloodstream slowly throughout the day, which may provide longer-lasting effects than nasal sprays. Injectable Selank usually comes in strengths of 2.5-5mg/mL.

N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is a modified version of Selank with an acetylated N-terminus and amidated C-terminus. These modifications help protect it from breaking down too quickly in the body.

N-Acetyl Selank Amidate may offer several advantages over standard Selank. It demonstrates enhanced bioavailability (30-50% higher than standard Selank), an extended half-life (4-6 hours compared to Selank’s 2-3 hours), improved blood-brain barrier penetration, and increased metabolic stability.

These improvements mean N-Acetyl Selank Amidate can be taken less often while still being effective. However, there isn’t much clinical research on this modified version, so its safety profile isn’t well established. Some researchers recommend starting with standard Selank before trying the more potent modified version to better gauge how patients respond.

Selank Dosage Guidelines

Intranasal Dosage Chart

Purpose	Dosage Range	Frequency	Duration
General Use	150-300 mcg	1-2x daily	2-4 weeks
Clinical Use	450 mcg (75 mcg per drop, 2 drops, 3x daily)	3x daily	Up to 14 days
Research Protocols	Up to 2700 mcg	Split in 3 daily doses	Up to 21 days
Nootropic Effects	300-600 mcg	1-2x daily	2-4 weeks
Anxiety Management	300-900 mcg	1-3x daily	2-4 weeks

According to Russian clinical guidelines, the intranasal formulation is given as two drops (75mcg per drop) of 0.15% solution three times daily for up to 14 days. Research studies have used doses up to 2700mcg daily, divided into three doses.²

For convenient home use, many practitioners recommend one spray in each nostril daily.

Subcutaneous Dosage Chart

Purpose	Dosage Range	Frequency	Duration
General Use	150-300 mcg	Once daily	2-4 weeks
Cognitive Enhancement	100-200 mcg	Every morning	4-6 weeks
Anxiety Management	200-500 mcg	Morning and afternoon	4-6 weeks
Research Protocols	250-500 mcg	Once daily	Variable

For under-the-skin (subcutaneous) injection, Dr. William Seeds suggests using 100-300 mcg of Selank daily.³ Most people tolerate this amount well. Since the body processes Selank gradually when injected into the fat layer under the skin, you typically don’t need to divide this into multiple shots throughout the day.

Dosage Guidelines for Therapeutic Purposes

For Anxiety and Stress Relief

For managing anxiety and stress, dosage recommendations are:

• Intranasal: 300-900 mcg, administered 1-3 times daily
• Subcutaneous: 200-500 mcg (0.04-0.1 mL at 5mg/mL concentration), administered every morning and afternoon, preferably in a fasted state

In animal studies examining Selank’s anxiolytic effects, a dose of 300 μg/kg was found to be most effective.⁴ Clinical observations suggest Selank may reduce anxiety without the sedative side effects associated with traditional anxiolytics like benzodiazepines.⁵

For Cognitive Enhancement

When used primarily for cognitive enhancement, recommended dosages are:

• Intranasal: 300-600 mcg, administered 1-2 times daily
• Subcutaneous: 100-200 mcg (0.02-0.04 mL at 5mg/mL concentration), administered every morning, preferably in a fasted state

Selank has shown potential to improve learning, memory, and concentration without stimulant-like side effects.⁶ The cognitive-enhancing properties may be due to its influence on neurotransmitters and BDNF levels in the brain.

Cycling Protocols and Considerations

It’s generally recommended to take breaks when using Selank to prevent your body from becoming less responsive to its effects on the GABA system, though we don’t have much long-term research on this. Common cycling schedules include:

• 4-6 weeks on, followed by 2-4 weeks off
• 2 weeks on, at least 1 week off, then another 2-week course if needed
• Following the Russian clinical protocol of 14 days on, 1-3 weeks off before repeating the 14-day course

These cycling protocols help maintain effectiveness while potentially reducing any risk of tolerance development. The specific protocol chosen may depend on the individual’s response and the purpose for using Selank.

Combination Therapy with Semax

Semax and Selank work together to enhance brain function in complementary ways. Selank primarily reduces anxiety by affecting GABA pathways and increasing BDNF, while Semax improves cognitive abilities by boosting BDNF and activating dopamine systems.

When taken together, these peptides create a balanced effect: Semax provides cognitive enhancement while Selank reduces anxiety.⁷ This combination may offer better overall brain benefits than using either compound by itself.

Dosage Guidelines

Intranasal Administration (Preferred Method):

Time	Selank Dose	Semax Dose	Combined Effect
Morning	150-300 mcg	100-200 mcg	Cognitive activation + stress buffer
Afternoon	150-300 mcg	–	Sustained anxiety control
Evening	–	100-200 mcg*	Neuroregenerative support

*Evening Semax dosing only recommended for specific rehabilitation protocols

Subcutaneous Injection Protocol:

Compound	Daily Dose	Frequency	Notes
Selank	200-400 mcg	Single morning	Avoid late dosing
Semax	300-600 mcg	Split 2x daily	Morning/early afternoon

Key Considerations

Start with Selank alone for 3-5 days before introducing Semax to assess individual tolerance.

Cycling Strategy:

• 6 weeks on / 2 weeks off for maintenance
• 8 weeks on / 4 weeks off for therapeutic applications

Synergistic Effects:

• Combined BDNF upregulation enhances neuroplasticity
• GABA/dopamine balance improves stress resilience

Adverse Effects:

• Most common: Mild nasal irritation (12-18% cases)
• Rare: Headaches (2-3%), transient blood pressure changes (1-2%)
• Contraindications: Concurrent MAOI use, acute stroke recovery phase

Special Dosing Considerations

Body Weight Factors

Dosage requirements may vary based on body weight. The distribution of peptides in the body differs between individuals weighing up to 100 kg and those weighing more than 100 kg, partly due to differences in fatty tissue distribution. Some guidelines suggest:

• For preventive purposes: 1 capsule for people weighing up to 100 kg, 2 capsules for people weighing more than 100 kg
• For regenerative effects: 2 capsules for people weighing up to 100 kg, 3 capsules for people weighing more than 100 kg

When using injectable or intranasal Selank, similar principles may apply, with larger individuals potentially requiring doses in the upper recommended ranges.

Administration Timing

For optimal effects, some protocols recommend administering Selank:

• In a fasted state when possible
• Consistently at the same time each day
• For anxiety, potentially dividing doses between morning and afternoon
• For cognitive enhancement, preferably in the morning

Safety and Side Effects of Selank

Selank is generally reported to have minimal side effects compared to traditional anti-anxiety medications. However, potential adverse effects may include:

• Headache
• Nasal irritation (with intranasal administration)
• Mood swings or restlessness (rare, due to effects on neurotransmitters)
• Potential allergic reactions
• Possible interactions with other medications affecting the central nervous system

It’s important to note that while interactions are not well-documented, Selank’s effects on neurotransmitters may theoretically interfere with other medications that affect the central nervous system, such as antidepressants or anti-anxiety drugs.

Takeaway

Selank is a promising peptide that can reduce anxiety, enhance cognition, and help manage stress. Dosages vary based on how it’s taken, what it’s used for, and individual factors like body weight. Research suggests using 150-900 mcg daily for nasal sprays or 100-500 mcg daily for injections under the skin, with specific amounts based on desired benefits.

For best results and safety, experts recommend cycling Selank—using it for 2-6 weeks followed by breaks of 1-4 weeks. While Selank appears safer with fewer side effects than traditional anti-anxiety medications, it’s still mainly a research peptide in most countries. All use should be under proper medical guidance.

As research advances, these dosage guidelines may change to improve benefits and reduce risks. Anyone interested in Selank should first talk with healthcare providers who understand peptide therapies.

References

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/ ↩︎
2. https://pubmed.ncbi.nlm.nih.gov/26356395/ ↩︎
3. https://www.perlego.com/book/2898727/peptide-protocols-volume-one-pdf ↩︎
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC5322660/ ↩︎
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC4757669/ ↩︎
6. https://pubmed.ncbi.nlm.nih.gov/20919548/ ↩︎
7. https://pubmed.ncbi.nlm.nih.gov/32342318/ ↩︎