Imagine you start taking a therapeutic compound with high spirits. But then a slight inconvenience makes you entirely stop the therapy. Wouldn’t it be frustrating?
Whether you are exploring TB-500 for the first time or you have been a seasoned pro in the peptide world for a long time, it is better to know all the positives and downsides to make informed health decisions.
It is crucial to understand which side effects of TB-500 are common and which ones are severe so that you know what to tolerate and which needs immediate medical help.
In this article, we will explore TB-500 side effects, benefits, and the factors affecting the side effects of TB-500.
What is TB-500? What Does TB-500 Do?
People often get confused between TB-500 and TB-4. TB-4 contains 43 amino acids and is present in limited quantities in the body. So, scientists derived the small fragment containing the most healing potential and named it TB-500 (aka thymosin beta-500). Both terms are interchangeably used, so don’t get confused; they are almost the same thing.
According to a study published in Mechanisms of Ageing and Development, TB-500 speeds up the healing of muscles, bones, joints, and tendons. It holds the potential to heal multiple organs, including the liver, kidneys, heart, lungs, brain, and skin. And the healing mechanisms are pretty much the same, regardless of the organ.
A review article by Annals of the New York Academy of Sciences reported that TB-500 forms blood vessels and migrates cells to the damaged area for quick recovery. This makes it particularly popular among those who play outdoor games and get frequent injuries. That’s why TB-500 is considered one of the best peptides for athletic performance.
TB-500 Benefits
A review article published in the Expert Opinion on Biological Therapy indicated that TB-500 is a multi-functional peptide.
Several preclinical and clinical studies have proven the TB-500 peptide benefits, as shown below:
Repairs Tendons and Ligaments
TB-500 peptide is best for treating tendon and ligament injuries that occur suddenly due to an accident or gradually due to repeated motion. It also alleviates wear and tear caused by aging or other medical reasons. The peptide stimulates the production of collagen (a main component of tendons), which contributes to their healing.
Like other tons of happy TB-500 users, a netizen shared his tendon healing experience:
Dealing with tendonitis and 7 months of debilitating tennis elbow that physiotherapy did little to help and over-the-counter painkillers were just partially numbing. 5 weeks of TB500 and BPC157 brought the pain from an 8 to a 2 and I have full range of motion now. Needless to say, it is a damn miracle and I’ll never be without it.
A preclinical study published in the Regulatory Peptides revealed the effect of TB-500 on medial collateral ligament (MCL) in rats. MCL is a common ligament injury that affects knees after athletic accidents.
It was observed that TB-500 treatment in rats:
- Improved the stiffness and diameter of collagen fibrils
- Fixed the packing of the new collagen fibers
- Healed the injured ligament tissues
- Improved the function of knee joints
Due to its proven tendon-repairing potential, TB-500 is categorized as one of the best peptides for tendon repair.
Pro tip: Using foot arch support accelerates injury recovery. It acts as a shock absorber, aligns posture, and decreases strain on muscles, tendons, ligaments, joints, and fascia (like Achilles tendinitis and plantar fasciitis).
Boosts Cardiovascular Health
Based on multiple preclinical trials, a study by International Immunopharmacology suggested that TB-500 may show therapeutic potential against mild alterations in the human heart caused by aging.
A netizen shared his experience with TB-500, saying:
It is safe, i have proof of that being on tb500 for 6 weeks my heart was better than it was the year before i have little bad heart i did ghk-cu with it, i really recommend it. But be sure your source is legit =)
During heart attack, 25 % of the cells are immediately damaged. About 0.5-1% of human heart cells tend to renew annually. However, this natural renewal rate is insufficient to compensate for the cell loss after a heart attack.
That’s where TB-500 does its magic. A preclinical study published in Frontiers in Pharmacology revealed the therapeutic effect of TB-500 on the cardiac system of rats. The peptide helped in:
- Preserving damaged heart tissues
- Preventing death of the heart cells
- Improving the blood-pumping ability of the heart
So, TB-500 might show a protective effect on those recovering from cardiac issues.
Note: While TB-500 has heart-health benefits, if you are a heart patient, don’t use it without a doctor’s prescription.
Fights Inflammation
Inflammation is the root cause of several health conditions. However, TB-500 reduces inflammatory agents to fight inflammation and shows alleviative potential against multiple conditions. According to a study published in Chronic Diseases and Translational Medicine, TB-500 mitigates fatty liver disease — a health condition associated with obesity.
Another preclinical research recently published in Zagazig University Medical Journal indicated that TB-500 treatment improved the condition of rats’ lungs by:
- Reducing pulmonary fibrosis
- Decreasing inflammation
- Fixing the tissue structure of the lungs
Also, it was suggested that TB-500 may show protective efficacy against the human disorders caused by fibrosis.
Is TB-500 Safe?
According to a clinical study published in the Journal of Cellular and Molecular Medicine, 30 Chinese individuals received single-dose and multi-dose treatments of TB-500. The patients showed minimal side effects.
Hence, the study concluded that TB-500 is safe enough to be used in another ongoing clinical trial. However, the research on TB-500 is in preliminary stages. Its clinical efficacy for healing all human organ systems is not established yet.
However, just like we cannot be 100% sure about any supplement or drug, this peptide may not work for certain health conditions despite being a miracle healing peptide.
Don’t use TB-500 if you are:
- A cardiovascular patient
- Have an autoimmune disorder
- Face blood clotting disorder
- A pregnant or breastfeeding woman
- A cancer patient or convalescent or have a family history of cancer
Note: If you are a healthy adult, you may buy TB-500 only from a top-quality source (like Biolongevity Labs). Avoid using counterfeit peptides, as they could be unsafe for you.
TB-500 Side Effects
Despite being a well-tolerated peptide, TB-500 may show the following side effects.
Common Side Effects
Most of the side effects are temporary and mild. Plus, they usually subside after some time. These common side effects include:
- Nausea
- Fatigue
- Headache
- Muscle pain
- Lethargy
Some individuals may experience a head rush right after injecting TB-500, but it usually goes away within a few minutes.
A TB-500 user shared:
If you have an issue with irritable bowel syndrome or bloating, start low with tb-500. It can bloat you intensely. I had insane bloating with it.
Therefore, be mindful of using TB-500 if you have irritable bowel syndrome or bloating issues.
Discomfort at Injection Site
Although using hygienic and right injection techniques prevents infection, you may still feel some discomfort at the injection site, including:
- Pain
- Irritation
- Redness
- Swelling
Rotate injection sites a bit to prevent repeatedly irritating the same point.
TB-500 and Allergic Reactions
TB-500 may cause allergic reactions in a few individuals. The anaphylaxis or allergic reactions include:
Mild reactions:
- Skin rashes
- Hot flashes
- Face swelling
- Itching
Severe reactions:
- Difficulty in breathing
- Sweating
Note: The body may take some time to adapt to the TB-500. So don’t panic if you experience mild side effects. However, if you experience severe side effects, visit an ER immediately.
TB-500 for Arthritis – A Friend or Enemy
Multiple studies have proved the anti-inflammatory role of TB-500.
Since arthritis is an inflammatory condition, TB-500 is considered to have therapeutic efficacy against it. However, we highly recommend consulting your doctor if you want to use TB-500 for arthritis.
The reason?
While TB-500 reduces inflammation and repairs tissues, it’s unproven whether it helps with arthritis. A study published in Biomedical Reports reported the occurrence of TB-4 in the joint fluid of rheumatoid arthritis patients.
The detection of TB-4 in joint fluid aroused mixed reactions. Some scientists speculated that the high TB-4 level in the serum and joint fluid was to fight inflammation and protect joint bones. In contrast, others were unsure if it fights inflammation or induces inflammation.
There was no positive or negative conclusion to the study. It was indicated that TB-500 against arthritis needs further research.
TB-500 – An Anti-Cancer or Pro-Cancer Peptide
Like arthritis, the role of TB-500 is controversial in cancer research. According to a study published in Haematologica, TB-4 (aka TB-500) suppresses cells of multiple myeloma (a cancer of plasma cells).
Another research reported that TB-4 may stop the NSCLC (non-small cell lung cancer cells) from spreading further. Both of the studies reveal that TB-500 may show anti-cancer properties.
However, a study published in Oncogene indicated that overexpression of TB-4 is linked with the progression of colon cancer cells. The peptide may multiply the cancer cells, weaken the bonds among cells, and alter their internal structure.
Additionally, TB-4 may stimulate certain cancer-related genes to increase the growth and movement of cancer cells.
In short, the role of TB-500 in cancer is confusing. Also, more research is needed to get a definite conclusion. However, to keep you on the safe side, we would suggest you avoid TB-500 if you are or have been a cancer patient.
BPC-157 and TB-500 Side Effects
It is crucial to reduce the BPC-157 and TB-500 dosage when used as a stack. Anecdotal evidence suggests mismanagement in dosing could cause reactions such as:
Effect on the Immune System
Both peptides can elicit immune responses, which could lead to unexpected allergic reactions in the body, specifically due to their long-term use.
Mild allergic reactions include itching or skin irritation. Some individuals may also experience shortness of breath or dizziness.
Effect on Actin and Myosin
Both peptides influence muscle contractions by regulating the proteins (actin and myosin). However, overstimulation of actin and myosin due to incorrect dosing may cause muscle spasms or affect muscle contractions.
Side Effects Shared by TB-500 and BPC-157 Users
While most TB-500 and BPC-157 users shared their positive reviews, we got to see a couple of users sharing side effects as well:
A TB-500 and BPC-157 stack user shared:
I’ve experienced excessive sweating while taking tb500 along with bcp157 for rotator cuff injury. Now I’m waking up at night soaked in sweat, my pillow is soaked too. I find the sweating can just come on out of nowhere even during the day.
Another netizen shared their experience, saying:
I have been taking tb500 and BPC 157, I started having aches and pains like arthritis all over my body.
While most people use the Wolverine stack of TB-500 and BPC-157 to accelerate recovery and endurance, it is crucial to first explore the distinct features of TB-500 vs. BPC-157. This will help you decide whether you should take any single peptide or the stack.
Factors that Influence Side Effects of TB-500
Multiple factors influence the side effects of TB-500, as shown below:
- Dosage: High TB-500 dosing, especially when beginning TB-500 treatment, may show increased side effects.
- Injection Technique: Using an inaccurate injection technique could cause tissue damage or localized infection.
- Interaction with Other Compounds: Be mindful of the drugs, supplements, or peptides you are using with the TB-500. The peptide tends to react with a few other compounds, causing side effects.
- Storage: Placing TB-500 in high temperatures can affect its function and cause side effects. So, store TB-500 at room temperature, between 20 to 25°C (68 to 77°F), to retain its effectiveness.
- Optimal Environment: Keep TB-500 away from sunlight, as ultraviolet rays can break down this peptide. Also, keep it in a moisture-free environment. Placing it in high humidity could lead to condensation inside vials, which may promote bacterial growth or make it useless by breaking peptide bonds.
How to Take TB-500 Safely
Keep the following points in mind for the safe and effective administration of TB-500:
- Clean Injection Site: Before injections, always use a new alcohol swab to clean your injection site and the rubber stopper of the TB-500 bottle to reduce the contamination risk.
- Massage the Injection Site: After injection, softly massage the injection site to enhance the absorption of TB-500 into the tissues.
- Take Breaks: Take a break after each TB-500 dosing cycle to prevent long-term side effects.
TB-500 has systemic effects — that means it shows efficacy all over the body even if injected away from the damaged area. However, it is recommended that TB-500 be injected close to the injury site to accelerate healing.
Pro tip: While it is convenient to take TB-500 nasal spray or TB-500 pills, the most effective way to take the TB-500 dosage is through injections.
Frequently Asked Questions (FAQs)
Explore the answers to your frequently asked questions below:
Does TB-500 Interfere with Hormonal Balance?
Well, taking the optimum TB-500 dose and following a proper regimen may not interfere with hormonal balance.
Other performance-enhancing compounds like steroids and SARMs (selective androgen receptor modulators) may act on androgen receptors and suppress testosterone.
However, according to anecdotal evidence, testosterone levels may increase by around 500 points if the individual is already on TRT (testosterone replacement therapy).
That’s why remember to take breaks between TB-500 treatment cycles, as prolonged therapy could slightly affect bodily functions and hormones.
Is Nausea a Common Side Effect of TB-500?
It depends. Some TB-500 users did not experience any side effects at all, while a few experienced mild and temporary reactions, like nausea and headache. So, there’s no definite answer to this question.
The certainty and frequency of TB-500 side effects are subjective.
Are there Age Restrictions for TB-500 Use?
TB-500 is strictly prohibited for anyone under 18. However, we suggest you wait until you reach your 20s.
If you are under 20, focus more on increasing your physical activity, eating a well-balanced diet, and getting ample rest for muscle healing.
Conclusion – TB-500 Peptide Side Effects
To some, the TB-500 craze may seem like fast fashion. However, its trend seems to be persistently growing due to its potential benefits for musculoskeletal healing and recovery.
It is important to take precautionary measures, use the right dose administration technique, and consult a healthcare professional to determine the right TB-500 dosage for your needs.
Also, be mindful that mild and temporary side effects are common. However, if you face extreme allergic reactions or other side effects, stopping the treatment and visiting your doctor is crucial.
